HFMSE (Hammersmith Functional Motor Scale)

The HFMSE (Hammersmith Functional Motor Scale) is an endpoint used to assess motor function. According to the Roche Holding AG — Evrysdi EMA EPAR public assessment report, HFMSE total scores range at baseline from 0-48 points. It serves as a measure in clinical trials, often appearing as a primary or secondary endpoint to evaluate the efficacy of treatments.

Regulatory reviews in this library utilize the HFMSE to quantify treatment effects. For instance, in the Novartis AG — Itvisma EMA EPAR public assessment report, the LSM change from baseline in HFMSE total score was 2.39 points. The Biogen Inc. — Spinraza FDA Review reported a mean (SD) change from baseline on day 715 of -0.65 (8.49). Additionally, the Roche Holding AG — Evrysdi EMA EPAR public assessment report noted a difference from placebo in HFMSE total score change from baseline of 0.58.