Body weight reduction
Metabolic· appears in 400+ cited findings in this library
What it is and how the reviews use it
Body weight reduction is an endpoint used in regulatory review documents to assess changes in a subject's body weight. It is frequently measured as a percentage change from baseline or as an absolute change in kilograms. This endpoint can serve as a primary or secondary outcome in clinical trials, particularly for drugs targeting metabolic conditions, obesity, or diabetes.
Regulatory reviews in this library frequently report body weight reduction. For instance, the RHYTHM — Imcivree FDA Review noted an "Average weight loss" of 9.7%. The JANSSEN PHARMS — Invokana FDA Review reported a "Body Weight % change from baseline" of -3.9%. The Boehringer Ingelheim — Jardiance FDA Review highlighted a "Difference in Body Weight from glimepiride (adjusted mean)" of -5.9%.
Real examples — cited to the source page
| Imcivree | Average weight loss | 9.7 % | RHYTHM — Imcivree FDA Review, p.11 |
| Invokana | Body Weight % change from baseline | -3.9 % | JANSSEN PHARMS — Invokana FDA Review, p.36 |
| Jardiance | Difference in Body Weight from glimepiride (adjusted mean) | -5.9 % | Boehringer Ingelheim — Jardiance FDA Review, p.29 |
| Jentadueto | Body weight change from baseline vs placebo | 1.46 kg | Boehringer Ingelheim — Jentadueto EMA EPAR variation assessment report, p.28 |
| Zepbound | AHI improvement from baseline with body weight reduction | 50 % | ELI LILLY AND CO — Zepbound (Autoinjector) FDA Review, p.212 |
| Mounjaro | Body weight reduction (comparator-subtracted) for tirzepatide 10 mg | -3.6 to -11.5 kg | Eli Lilly and Company — Mounjaro FDA Review, p.19 |
| Rybelsus | Body Weight Change from Baseline | -4.36 kilograms | NOVO — Rybelsus FDA Review, p.23 |
| Saxenda | Mean weight loss | 7.5 % | Novo Nordisk A S — Saxenda EMA EPAR public assessment report, p.63 |
Different drugs were studied in different trials — these values are not head-to-head comparisons.
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Figures are as stated in the cited source documents. Educational reference only — not medical or investment advice.