EASI (Eczema Area and Severity Index)
Immunology· appears in 400+ cited findings in this library
What it is and how the reviews use it
The EASI (Eczema Area and Severity Index) is a rating scale used to assess the severity and extent of eczema. In the provided regulatory review documents, it functions as a key endpoint in clinical trials for treatments targeting eczema. Specifically, EASI-75, which represents a 75% improvement in the EASI score from baseline, is frequently used as a measure of treatment efficacy. It serves as a primary or secondary endpoint to evaluate the response to various therapeutic interventions.
Regulatory reviews in this library consistently utilize EASI-75 to quantify treatment success. For instance, the Almirall S A Ebglyss EMA EPAR report shows a treatment difference in EASI 75 response rate of 33.3%. The Sanofi Dupixent EMA EPAR report notes that 22.4% of patients achieved EASI-75 at week 52 (Not Subset 3, placebo + TCS). Furthermore, the Pfizer Inc. Cibinqo FDA Review reported a 28% difference from placebo in EASI-75 response rate.
Real examples — cited to the source page
| Almirall S A — Ebglyss | Treatment difference in EASI 75 response rate | 33.3 | Ebglyss EMA EPAR public assessment report, p.90 |
| Sanofi — Dupixent | Proportion of patients with EASI-75 at week 52 (Not Subset 3, placebo + TCS) | 22.4 | Dupixent EMA EPAR public assessment report, p.42 |
| Pfizer Inc. — Cibinqo | Difference from placebo in EASI-75 response rate (%) | 28 | Cibinqo FDA Review, p.92 |
| Galderma — Nemluvio | EASI-75 (proportion) | 43.5 | Nemluvio EMA EPAR public assessment report, p.109 |
| ABBVIE — Rinvoq | EASI-75 (Adults) | 79 | Rinvoq FDA Review, p.148 |
| REGENERON PHARMACEUTICALS — Dupixent | EASI-75 improvement | 76.1 | Dupixent FDA Review, p.79 |
| Turn Therapeutics Inc. | EASI-75 improvement (%) | 69.2 | SEC 8-K, p.2 |
| Apogee Therapeutics, Inc. | EASI-75 response rate (%) | 65.9 | SEC 8-K, p.2 |
Different drugs were studied in different trials — these values are not head-to-head comparisons.
Explore the full evidence
Every EASI finding in the library — searchable and answerable in plain language — is in the Immunology research library →
Figures are as stated in the cited source documents. Educational reference only — not medical or investment advice.